Product Information
Melatonin is a hormone which occurs naturally in the body. Under certain circumstances the production can be limited and it is difficult to fall asleep. OPTAMINS Melatonin + Valerian + Lemon Balm contributes to the reduction of time taken to fall asleep as it contains 1 mg Melatonin.
Melatonin levels change throughout life. In humans, melatonin production start at 3-4 months of age. Levels increase progressively during childhood, peaking between the ages of 8-10 years. Melatonin synthesis decreases dramatically during puberty. After the age of 40-45 years, melatonin levels decrease progressively, and by the age of 70 they represent barely 10% of prepubertal levels.1
In healthy individuals, melatonin is synthesized in response to darkness, between 20:00 and 22:00 o’clock, peaking between 00:00 and 03:00 o’clock, regardless of the sleep stage. After that, melatonin synthesis progressively decreases, remaining very low during the day. At night, peak plasma melatonin levels range from 100 to 200 pg/ml; concentrations range from 10 – 30 pg/ml during the day. Daylight exposure is the main factor in the regulation of melatonin secretion. Exposure to artificial light between 00:00 and 04:00 inhibits melatonin secretion.2
Melatonin resynchronizes the circadian rhythm and the sleep-wake cycle, and also regulates the reproductive cycle.1
1 Poza JJ, Pujol M, Ortega-Albás JJ, Romero O; Insomnia Study Group of the Spanish Sleep Society (SES). Melatonin in sleep disorders. Neurologia (Engl Ed). 2022 Sep;37(7):575-585. doi:10.1016/j.nrleng.2018.08.004. Epub 2020 Sep 18. PMID: 36064286.
2 Claustrat B, Leston J. Melatonin: Physiological effects in humans. Neurochirurgie. 2015 Apr-Jun;61(2-3):77-84. doi: 10.1016/j.neuchi.2015.03.002. Epub 2015 Apr 20. PMID: 25908646.